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Briefly, l-norcarnitine (3-hydroxy-4-dimethylaminobutyric acid) was prepared from l-carnitine (Chem Impex International) with thiophenol (Sigma-Aldrich) in N , N -dimethylaminoethanol (Sigma-Aldrich) and then was converted to its sodium salt with sodium hydroxide by the method of Colucci et al

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At position 3 on the chain Glu(E) was substituted with Arg(R), which gives the name LR3